羟基酪醇的药理作用研究进展

罗成, 陈明智, 李艳

中国药学杂志 ›› 2019, Vol. 54 ›› Issue (20) : 1642-1646.

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中国药学杂志 ›› 2019, Vol. 54 ›› Issue (20) : 1642-1646. DOI: 10.11669/cpj.2019.20.002
综 述

羟基酪醇的药理作用研究进展

  • 罗成, 陈明智, 李艳*
作者信息 +

Progresses in Pharmacological Effects of Hydroxytyrosol

  • LUO Cheng, CHEN Ming-zhi, LI Yan*
Author information +
文章历史 +

摘要

长期摄入橄榄油有助于降低心血管疾病、神经系统疾病、癌症等的发生风险。橄榄油中的次要化合物,特别是明星分子羟基酪醇,在橄榄油诸多健康效应中发挥了重要作用。作为一种多酚类化合物,羟基酪醇既可以直接清除氧化性物质,又可以通过调节以核转录因子E2相关因子2(nuclear factor erythroid-2 related factor 2,Nrf2)为核心的二相酶抗氧化系统间接抑制氧化应激,在预防/治疗多种氧化损伤相关疾病中具有巨大潜力。笔者重点介绍羟基酪醇在防治神经系统疾病、心血管疾病、代谢综合征、炎症、肿瘤等疾病方面取得的最新进展。

Abstract

Long-term consumption of olive oil helps reduce the risks of developing a series of diseases including cardiovascular disease, nervous system disease, cancer, etc. The minor compounds of olive oil, especially the star molecule——hydroxytyrosol, play an important role in these beneficial effects on human health. As a polyphenolic compound, hydroxytyrosol not only act as antioxidant and scavenge oxidizing substances directly, but also inhibit oxidative stress by regulating the Nrf2 antioxidant system. Thus, hydroxytyrosol has great potential in the prevention and treatment of oxidative damage related diseases. This review focuses mainly on recent progresses in pharmacological effects of hydroxytyrosol on nervous system disease, angiocardiopathy, metabolic syndrome, inflammation and cancer.

关键词

羟基酪醇 / 神经系统疾病 / 心血管疾病 / 炎症 / 肿瘤

Key words

hydroxytyrosol / nervous system disease / angiocardiopathy / inflammation / cancer

引用本文

导出引用
罗成, 陈明智, 李艳. 羟基酪醇的药理作用研究进展[J]. 中国药学杂志, 2019, 54(20): 1642-1646 https://doi.org/10.11669/cpj.2019.20.002
LUO Cheng, CHEN Ming-zhi, LI Yan. Progresses in Pharmacological Effects of Hydroxytyrosol[J]. Chinese Pharmaceutical Journal, 2019, 54(20): 1642-1646 https://doi.org/10.11669/cpj.2019.20.002
中图分类号: R966   

参考文献

[1] BUCKLAND G, TRAVIER N, BARRICARTE A, et al. Olive oil intake and CHD in the European Prospective Investigation into Cancer and Nutrition Spanish cohort[J]. Br J Nutr, 2012, 108(11):2075-2082.
[2] COSTA C, TSATSAKIS A, MAMOULAKIS C, et al. Current evidence on the effect of dietary polyphenols intake on chronic diseases[J]. Food Chem Toxicol, 2017, 110:286-299.
[3] LUO C, LIU J K. The regulation mechanism of hydroxytyrosol as a mitochondrial nutrient [J]. Life Sci (生命科学), 2012, 24(10):1114-1120.
[4] LUO C, LIU J K. Advances in anti-cancer mechanisms of hydroxytyrosol[J]. Sci Sin Vit(中国科学:生命科学), 2014, 44 (1):14-20.
[5] YUAN J J, WANG C Z, YE J Z, et al. Enzymatic hydrolysis of oleuropein from olea europea (olive) leaf extract and antioxidant activities[J]. Molecules, 2015, 20(2):2903-2921.
[6] SKLAVOS S, GATIDOU G, STASINAKIS A S, et al. Use of solar distillation for olive mill wastewater drying and recovery of polyphenolic compounds[J]. J Environ Manage, 2015, 162:46-52.
[7] PASTOR A, RODRíGUEZ-MORATó J, OLESTI E, et al. Analysis of free hydroxytyrosol in human plasma following the administration of olive oil[J]. J Chromatogr A, 2016, 1437:183-190.
[8] SERRA A, RUBIó L, BORRÀS X, et al. Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake[J]. Mol Nutr Food Res, 2012, 56(3):486-496.
[9] AUNON-CALLES D, CANUT L, VISIOLI F. Toxicological evaluation of pure hydroxytyrosol[J]. Food Chem Toxicol, 2013, 55:498-504.
[10] HEILMAN J, ANYANGWE N, TRAN N, et al. Toxicological evaluation of an olive extract, H35: subchronic toxicity in the rat[J]. Food Chem Toxicol, 2015, 84:18-28.
[11] YE Z W, ZHANG J, TOWNSEND D M, et al. Oxidative stress, redox regulation and diseases of cellular differentiation[J]. Biochim Biophys Acta Gen Subjects, 2015, 1850(8):1607-1621.
[12] KITSATI N, MANTZARIS M D, GALARIS D. Hydroxytyrosol inhibits hydrogen peroxide-induced apoptotic signaling via labile iron chelation[J]. Redox Biol, 2016, 10:233-242.
[13] ZHENG A D, LI H, XU J, et al. Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation[J]. Br J Nutr, 2015, 113(11):1667-1676.
[14] MOHAN V, DAS S, RAO S B. Hydroxytyrosol, a dietary phenolic compound forestalls the toxic effects of methylmer cury-induced toxicity in IMR-32 human neuroblastoma cells[J]. Environ Toxicol, 2016, 31(10):1264-1275.
[15] HUANG H, CHEN J, LU H, et al. Iron-induced generation of mitochondrial ROS depends on AMPK activity[J]. Biometals, 2017,30(4):623-628.
[16] LOHREN H, BLAGOJEVIC L, FITKAU R, et al. Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes[J]. J Trace Elem Med Biol, 2015, 32:200-208.
[17] PAUL S, BHATTACHARJEE P, GIRI A K. Arsenic toxicity and epimutagenecity: the new LINEage[J]. Biometals, 2017, 30(4):505-515.
[18] MOYANO P, DE FRIAS M, LOBO M, et al. Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption[J]. Toxicology, 2018, 394:54-62.
[19] SONI M, PRAKASH C, SEHWAG S, et al. Protective effect of hydroxytyrosol in arsenic-induced mitochondrial dysfunction in rat brain[J]. J Biochem Mol Toxicol, 2017, 31(7):e21906.
[20] XU D, ZHANG B J, LIANG G, et al. Caffeine-induced activated glucocorticoid metabolism in the hippocampus causes hypothalamic-pituitary-adrenal axis inhibition in fetal rats[J]. PLoS One, 2012, 7(9):e44497.
[21] WALSH D M, SELKOE D J. Deciphering the molecular basis of memory failure in Alzheimer′s disease[J]. Neuron, 2004, 44(1):181-193.
[22] NARDIELLO P, PANTANO D, LAPUCCI A, et al. Diet supplementation with hydroxytyrosol ameliorates brain pathology and restores cognitive functions in a mouse model of amyloid-β deposition[J]. J Alzheimers Dis, 2018, 63(3):1161-1172.
[23] CRESPO M C, TOMÉ-CARNEIRO J, PINTADO C, et al. Hydroxytyrosol restores proper insulin signaling in an astrocytic model of Alzheimer′s disease[J]. Biofactors, 2017, 43(4):540-548.
[24] ST-LAURENT-THIBAULT C, ARSENEAULT M, LONGPRÉ F, et al. Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid-β-induced toxicity. Involvement of the NF-κB signaling[J]. Curr Alzheimer Res, 2011, 8(5):543-551.
[25] KUMAR H, LIM H W, MORE S V, et al. The role of free radicals in the aging brain and Parkinson′s disease: convergence and parallelism[J]. Int J Mol Sci, 2012, 13(8):10478-10504.
[26] HASTINGS T G, LEWIS D A, ZIGMOND M J. Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections[J]. Proc Natl Acad Sci USA, 1996, 93(5):1956-1961.
[27] YU G H, DENG A J, TANG W B, et al. Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity[J]. Neurochem Int, 2016, 96:113-120.
[28] GOLDSTEIN D S, JINSMAA Y, SULLIVAN P, et al. Comparison of monoamine oxidase inhibitors in decreasing production of the autotoxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) in PC12 cells[J]. J Pharmacol Exp Ther, 2016, 356(2):483-492.
[29] GOLDSTEIN D S, JINSMAA Y, SULLIVAN P, et al. 3,4-Dihydroxyphenylethanol (hydroxytyrosol) mitigates the increase in spontaneous oxidation of dopamine during monoamine oxidase inhibition in PC12 cells[J]. Neurochem Res, 2016, 41(9):2173-2178.
[30] WEBER C, NOELS H. Atherosclerosis: current pathogenesis and therapeutic options[J]. Nat Med, 2011, 17(11):1410-1422.
[31] CATALÁN U, LÓPEZ DE LAS HAZAS M, RUBIÓ L, et al. Protective effect of hydroxytyrosol and its predominant plasmatic human metabolites against endothelial dysfunction in human aortic endothelial cells[J]. Mol Nutr Food Res, 2016, 59(12):2523-2536.
[32] SCODITTI E, NESTOLA A, MASSARO M, et al. Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition[J]. Atherosclerosis, 2014, 232(1):17-24.
[33] LÓPEZ-VILLODRES J A, ABDEL-KARIM M, DE LA CRUZ J P, et al. Effects of hydroxytyrosol on cardiovascular biomarkers in experimental diabetes mellitus[J]. J Nutr Biochem, 2016, 37: 94-100.
[34] MATEOS R, MARTÍNEZ-LÓPEZ S, BAEZA ARÉVALO G, et al. Hydroxytyrosol in functional hydroxytyrosol-enriched biscuits is highly bioavailable and decreases oxidised low density lipoprotein levels in humans[J]. Food Chem, 2016, 205:248-256.
[35] CASTANER O, COVAS M I, KHYMENETS O, et al. Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans[J]. Am J Clin Nutr, 2012, 95(5):1238-1244.
[36] LÁGER C L, CARBONNEAU M A, MICHEL F, et al. A thromboxane effect of a hydroxytyrosol-rich olive oil wastewater extract in patients with uncomplicated type I diabetes[J]. Eur J Clin Nutr, 2005, 59(5):727-730.
[37] ROSILLO M Á, SÁNCHEZ-HIDALGO M, CASTEJÓN M L, et al. Extra-virgin olive oil phenols hydroxytyrosol and hydroxytyrosol acetate, down-regulate the production of mediators involved in joint erosion in human synovial cells[J]. J Funct Foods, 2017, 36:27-33.
[38] DELL″AGLI M, MASCHI O, GALLI G V, et al. Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase[J]. Br J Nutr, 2008, 99(5):945-951.
[39] ZHANG Y, SOWERS J R, REN J. Targeting autophagy in obesity: from pathophysiology to management[J]. Nat Rev Endocrinol, 2018, 14(6):356-376.
[40] STEFANON B, COLITTI M. Hydroxytyrosol, an ingredient of olive oil, reduces triglyceride accumulation and promotes lipolysis in human primary visceral adipocytes during differentiation[J]. Exp Biol Med (Maywood), 2016, 241(16):1796-1802.
[41] DRIRA R, SAKAMOTO K. Hydroxytyrosol stimulates lipolysis via A-kinase and extracellular signal-regulated kinase activation in 3T3-L1 adipocytes[J]. Br J Nutr, 2014, 53(3):743-750.
[42] PRIORE P, GNONI A, NATALI F, et al. Oleic acid and hydroxytyrosol inhibit cholesterol and fatty acid synthesis in C6 glioma cells[J]. Oxid Med Cell Longev, 2017, 2017:9076052.
[43] CAO K, XU J, ZOU X, et al. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice[J]. Free Radic Biol Med, 2014, 67(1):396-407.
[44] PERSIA F A, MARIANI M L, FOGAL T H, et al. Hydroxytyrosol and oleuropein of olive oil inhibit mast cell degranulation induced by immune and non-immune pathways[J]. Phytomedicine, 2014, 21(11):1400-1405.
[45] PIROZZI C, LAMA A, SIMEOLI R, et al. Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD[J]. J Nutr Biochem, 2016, 30:108-115.
[46] TAKEDA Y, BUI V N, IWASAKI K, et al. Influence of olive-derived hydroxytyrosol on the toll-like receptor 4-dependent inflammatory response of mouse peritoneal macrophages[J]. Biochem Biophys Res Commun, 2014, 446(4):1225-1230.
[47] CETRULLO S, D′ADAMO S, GUIDOTTI S, et al. Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms[J]. Biochim Biophys Acta, 2016, 1860(6):1181-1191.
[48] FACCHINI A, CETRULLO S, D′ADAMO S, et al. Hydroxytyrosol prevents increase of osteoarthritis markers in human chondrocytes treated with hydrogen peroxide or growth-related oncogene α[J]. PLoS One, 2014, 9(10):e109724.
[49] TOTEDA G, LUPINACCI S, VIZZA D, et al. High doses of hydroxytyrosol induce apoptosis in papillary and follicular thyroid cancer cells[J]. J Endocrinol Invest, 2017, 40(2):153-162.
[50] SUN L J, LUO C, LIU J K. Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation[J]. Food Funct, 2014, 5(8):1909-1914.
[51] TERZUOLI E, GIACHETTI A, ZICHE M, et al. Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation[J]. Mol Nutr Food Res, 2016, 60:519-529.
[52] SARSOUR E H, GOSWAMI M, KALEN A L, et al. Hydroxytyrosol inhibits chemokine C-C motif ligand 5 mediated aged quiescent fibroblast-induced stimulation of breast cancer cell proliferation[J]. Age (Dordr), 2014, 36(3):9645.

基金

江西省自然科学基金项目资助(20161BAB215196);江西省教育厅科学技术项目资助(GJJ151021)
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